Dr. Jothi Lakshmi Nallasivam

E-mail: jothi@nitt.edu

 

Research Interest

  • Transition Metal Catalysis
  • Cross Coupling
  • Designing Novel Methodology
  • Synthesis of Bioactive Natural Products

 

Education:

Ph.D:  Mentor: Prof. Rodney A. Fernandes, Indian Institute of Technology Bombay, Maharashtra, India.

M.Sc: Mentor: Prof. Y. B. Basavaraju, Manasagangothri, University of Mysore, Karnataka

 

Research Grant

1. DST-SERB-CRG: CRG/2021/008121 (2021-2024 ongoing, 3-Years, 39.4 Lakhs)

2. NITT-Intitute Seed Grant (2021-2023 ongoing, 2 Years, 5 Lakhs)

3. DST-SERB-NPDF (2017-2019, 2-Years, 19.8 Lakhs)

 

Research Experience:

  • Postdoctoral Fellow: ″Titanium Mediated Radical cyclization″ Mentor: Prof. Tushar Kanti Chakraborty, Indian Institute of Science (IISc), Bangalore
  • CSIR-JRF and SRF: ″Development of Asymmetric Allylation, Bis-allylation, aza-Cope/aza-Prins Cyclization, Suzuki-Miyaura Coupling, Mono and Bis-arylation of γ-Vinyl-γ-butyrolactone″ Mentor: Prof. Rodney A. Fernandes, Indian Institute of Technology Bombay
  • CSIR-JRF: Mentor: Prof. Rodney A. Fernandes, IRCC, Indian Institute of Technology Bombay
  • Scientist: Syngene International Limited, Bangalore

 

Teaching: 20 May 2020 to till date

Assistant Professor, Department of Chemistry, NIT Tiruchirappalli

 

B.Tech

CHIR11 Chemistry Theory (Semester 1 & 2)

CHIR12 Chemistry Laboratory (Semester 1 & 2)

  • CSE 2019-23, Section - A, Jan-2020, S2
  • ME 2020-24, Section - A, July-2020, S1
  • EEE 2020-24, Section - B, Jan-2021, S2
  • ME 2021-2025, Section - B, July-2021, S1
  • EEE 2021-25, Section - B, Jan-2022, S2

 

M.Sc & Ph.D

CH629 Polymer Chemistry (Semester 3)

  • M.Sc 2019-21 & 2020-22 July-2020 & 2021, S3
  • Ph.D 2020-24 & 2021-25 July-2020 & 2021

 

CH609 Organic Preparation and Separation Laboratory

M.Sc 2020-22, Jan-2021, S1

 

Ph.D Ongoing

1. Ashish Kumar Tiwari

 

Post-graduate (M.Sc) Project

1. Mopi Lollen (M.Sc 2019-2021, S4)

2. Keerthivasan (M.Sc 2020-2022, S4)

3. Sivaranjani (M.Sc 2020-2022, S4)

 

DST Project Fellow: CRG/2021/008121

1. Ananda K. M (JRF project fellow)

 

Honors and Awards

2017: Awarded National Postdoctoral Fellowship (DST-SERB-NPDF)

2017: PhD Best Thesis Award, IIT Bombay

2012: Awarded as Senior Research Fellow (CSIR, July−2012 to July−2015), New Delhi.

2010: Awarded as Junior Research Fellow (CSIR, July−2010 to July−2012), New Delhi.

2009: Awarded as Junior Research Fellow (IRCC-IIT Bombay April 2009 to July 2010).

2009: Qualified National Eligibility Test (CSIR-LS-NET, July–2009), New Delhi.

2009: Qualified GATE 2009 examination.

 

Publications:

  1. (‒)-β-Pinene-based π-Allylpalladium Complex-Catalyzed Asymmetric Allylation of Bis-Imines. Nallasivam, J. L.; Fernandes R. A.* ChemistrySelect, 2020 doi.org/10.1002/slct.202002599).
  2. Titanocene(III)-Mediated 5-exo-trig Radical Cyclization: En Route to Spirooxindole-Based Tetrahydrofuran and Bicyclic Lactone. Nallasivam, J. L.; Chakraborty, T. K.* J. Org. Chem. 2019. (DOI:10.1021/acs.joc.9b02608).
  3. Catalytic Allylic Functionalization via π -Allyl Palladium Chemistry. Nallasivam, J. L.; Fernandes R. A.* Org. Biomol. Chem. 2019, 17, 8647. (DOI: 10.1039/c9ob01725a).
  4. Synthetic Modifications of Bifunctional Homoallylamines: Synthesis of 2-Arylpiperidines, (R)-Anatabine and (R)-Anabasine. Nallasivam, J. L.; Fernandes R. A.* Synth. Commun. 2019, 49, 2815. (DOI:10.1080/00397911.2019.1643890).
  5. A Protective-Group-Free Synthesis of Paraconic acids: Synthesis of (+)-Methylenolactocin, (+)-Phaseolinic acid, (+)-Nephrosteranic acid, (+)-Rocellaric acid, (+)-Nephrosterinic acid and (+)-Protolichesterinic acid. Nallasivam, J. L.; Fernandes R. A.* Org. Biomol. Chem. 2017, 15, 708. (DOI: 10.1039/c6ob02398c).
  6. Pd-Catalyzed Site-Selective Mono Allylic Substitution and Bis-Arylation by Allylic Directed C-H Activation of g-Vinyl-g-Lactone: Synthesis of g-(Aryl,Styryl)-β-Hydroxy Acids and Highly Substituted Tetrahydrofurans. Nallasivam, J. L.; Fernandes R. A.* J. Am. Chem. Soc. 2016, 138, 13238 (DOI: 10.1021/jacs.6b06438).
  7. A Concise Synthesis of Incrustoporin and its Analogues via Suzuki-Miyaura Coupling. Nallasivam, J. L.; Fernandes R. A.* ChemistrySelect, 2016, 1, 5137 (DOI: 10.1002/slct.201601379).
  8. Unimolecular 4-Hydroxy Piperidines:  New Ligands for Copper Catalyzed N-Arylation. Patil, P. H.; Nallasivam, J. L.; Fernandes, R. A.* Asian J. Org. Chem. 2015, 6, 552 (DOI: 10.1002/ajoc.201580601).
  9. Development of Unimolecular Tetrakis-Piperidine-4-ol as New Ligand for Suzuki-Miyaura Cross Coupling Reaction: Synthesis of Incrustoporin and Preclamol. Nallasivam, J. L.; Fernandes, R. A.* Eur. J. Org. Chem. 2015, 3558 (DOI: 10.1002/ejoc.201500353).
  10. A Cascade Aza-Cope/Aza-Prins Cyclization Leads to Piperidine Derivatives. Nallasivam, J. L.; Fernandes, R. A.* Eur. J. Org. Chem. 2015, 2012 (DOI: 10.1002/ejoc.201403607)
  11. Enantioselective Allylation of Imines Catalyzed by Newly Developed (−)-β-Pinene-Based π-Allylpalladium Catalyst: An Efficient Synthesis of (R)-α-Propylpiperonylamine and (R)-Pipecolic acid. Nallasivam, J. L.; Fernandes, R. A.* Org. Biomol. Chem. 2012, 10, 7789 (DOI: 10.1039/c2ob26188j).

 

Coferences/Seminars/Symposia Parcipited:

Oral Presentation:

  • Nallasivam, J. L.; Fernandes, R. A. "Aymmetric Allylation of Imines Catalyzed by Chiral π-Allyl Palldium Complexes." ACS on Campus, January 20th, 2016, IIT Bombay, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. A. "A Cascade Reactions and its Application in Suzuki-Miyaura Cross Coupling Reactions."  28th RSM 2016, February 12-13th, 2016, Takur College of Science and Commerce, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. "A Cascade aza-Cope/aza-Prins Cyclization Leads to Piperidine Derivatives: New Ligands for Suzuki-MiyauraCross Coupling Reactions." RAICS 2015 August 21-23rd, 2015, MNIT, Jaipur, India.

 

Poster Presention:

  • Nallasivam, J. L.; Fernandes, R. A. "A Cascade aza-Cope/aza-Prins Cyclization Leads to Piperidine Derivatives: New Ligands for Suzuki-Miyaura Cross Coupling Reactions." 16th Tetrahedron Symposium; Asia Edition, November 10-13th, 2015, Shanghai Institute of Organic Chemistry, China.
  • Nallasivam, J. L.; Fernandes, R. A. "Asymmetric catalysis and its applications in natural product synthesis.″ 16th CRSI National Symposium in Chemistry (NSC-15), February 7-9th, 2014, IIT Bombay, India.
  • Nallasivam, J. L.; Fernandes, R. A. "Enantioselective Allylation of Imines Catalyzed by (-)-Pinene Based π-AllylPalladium Catalyst: An Efficient Synthesis of (R)-α-Propylpiperonylamine and (R)-Pipecolic Acid." 10th J-NOST Symposium in Chemistry, December 4-6th, 2014, IIT Madras, India.
  • Nallasivam, J. L.; Fernandes, R. A. "Enantioselective Allylation of Imines Catalyzed by (-)-Pinene Based π-Allyl Palladium Complexes." 15th CRSI National Symposium in Chemistry (NSC-15), February 1-3rd, 2013, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
  • Nallasivam, J. L.; Fernandes, R. A.  "Development  of  Menthane  and  (-)-Pinene  Based  Chiral  π-Allyl  Palladium Catalysis in Asymmetric Allylation." Nallasivam, J. L.; Fernandes, R. A. IITB-ACS Symposium, October 2nd, 2012, IIT Bombay, Mumbai, India.
  • Nallasivam, J. L.; Fernandes, R. A. "(-)-β-Pinane Based Chiral π-Allyl Palladium Complexes Catalyzed Asymmetric Allylation of Imines." Nallasivam, J. L.; Fernandes, R. A. 3rd Indo-German Symposium on Frontiers of Chemistry, September 27-28th, 2011, IIT Bombay, India.

 

Contact:

 

Dr. Jothi Lakshmi Nallasivam

OJAS, Room. No. CH 215, Department of Chemistry

National Institute of Technology Tiruchirapalli

NIT campus 620015

Tamilnadu, India.

 

 

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